Instructions with the ED prefix consist of instructions that are not used as often as those in the main group.
| 7 | 6 | 5 | 4 | 3 | 2 | 1 | 0 | ||
|---|---|---|---|---|---|---|---|---|---|
| 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | NEG | |
| 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | RETN | |
| 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | RETI | |
| 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | ||
| 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | IM2 | |
| 0 | 1 | 0 | x | 0 | 1 | 1 | 0 | IMx | |
| 0 | 1 | 0 | x | 0 | 1 | 1 | 1 | LD | |
| 0 | 1 | 0 | x | 1 | 0 | 0 | 0 | LD | |
| 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | RRD (HL) | |
| 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | LD | |
| 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | RLD (HL) | |
| 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | ||
| 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | OUT (C) A | |
| 0 | 1 | x | x | 0 | 0 | 1 | 0 | SBC | |
| 0 | 1 | x | x | 1 | 0 | 1 | 0 | ADC | |
| 0 | 1 | x | x | x | 0 | 0 | 0 | IN r (C) | |
| 0 | 1 | x | x | x | 0 | 0 | 1 | OUT (C) r | |
| 0 | 1 | x | x | x | 0 | 1 | 1 | LD | |
| 1 | 0 | 1 | x | x | 0 | 0 | x | Block Memory | |
| 1 | 0 | 1 | x | x | 0 | 1 | x | Block IO |